"Translating 3D molecular atlas to brain function and dysfunction," by Xiao Wang, PhD, Associate Professor at MIT Chemistry and Broad Institute of MIT and Harvard

Spatially charting molecular cell types at single-cell resolution across the entire 3D volume of the brain is critical to illustrating the molecular basis of the tissue anatomy and functions. Yet, there is still a big gap between spatial cell atlas and tissue function.

In this presentation, I will introduce a few experimental and computational advances in the mapping of RNA life cycle in our lab that further enable multi-modality deep profiling of cell types and states in situ, bridging single-cell molecular profiles with single-cell functional status in intact biological tissues and accelerating gene-to-function discoveries in development and diseases.